The aim of present investigation deals with the development of time-dependent and pH sensitive press-coated tablets for colonspecific
drug delivery of Fluticasone propionate (FP). Fp is glucocorticoid exerts a potent anti-inflammatory action when
administered topically. The drug has been evaluated for the treatment of irritable bowel diseases (IBD) conditions such as Crohn’s
disease and ulcerative colitis. To overcome of poorly water soluble drug formulated as solid dispersion with different hydrophilic
carriers. The Solid dispersions (SDs) of FP with Pluronic® F-127 and PEG 6000 were prepared in three different ratios of 1:5, 1:10, and
1:15 by the solvent evaporation method and evaluated to deliver FP to the colon in a pre-solubilized form. The selected formula of
SDs was compressed into core tablets using drug compatible excipients and then press-coated tablet with the polymer mixture of
HPMC K15 (time dependent) and Eudragit® L100 (pH-responsive polymer). Differential scanning calorimetry and scanning electron
microscopy and powder X-ray diffraction, and Fourier transform infrared spectroscopy proved drug amorphization in SDS. The 1:15
FP/Pluronic® SDs showed the greatest improvement in solubility and dissolution. The best result of press coated tablet was given at
HPMC k15 to Eudragit L100 at polymer ratio 5:5 with coat weight 350 mg. This formula resisted pre-colonic pH values and showed
an adequate lag time for the intended colonic targeting (5 hrs), followed by release phase in phosphate buffer at pH 7.4. The
proposed coated tablets may provide a colonic delivery system for FP with improved dissolution for local action

Objective: The aim: This study aimed to develop mouth-dissolving tablets of Acrivastine, an antihistamine medication, in order to increase its oral bioavailability.
Patients and methods: Materials and methods: Different super disintegrants, such as crospovidone, croscarmellose sodium, and sodium starch glycolate, were used to make Acrivastine oral dispersible tablets (ODTs). These super disintegrants were utilized in various concentrations. The formulation (F3) with 6% w/w crospovidone had a fast disintegration time (less than 30 seconds) and practically total drug release within 10 minutes. All of the formulations were made using the direct compression method and proper diluents, binders, and lubricants. Fourier transform infrared spectroscopy (FTIR) tests were used to investigate the drug-ex¬cipient interaction, and all formulations demonstrated improved drug-excipient compatibility.

Aims Nigella sativa is recognized as a black seed. It is a grassy plant relating to the
Ranunculaceae family. There are various reports regarding this plant’s pharmacological
and biological action, like antihypertensive effects, antibacterial, anticancer, antioxidants,
antifungal, pain alleviating, anti-inflammatory, antidiabetic, and immune-modulatory effects.
This study aimed to compare the anti-microbial activity of aqueous and oil extract of Nigella
sativa against selected gram-positive and gram-negative bacteria.
Materials & Methods Nigella sativa aqueous and oil extracts were gathered via a retail
food shop (Al-Hilla) 2018. Gram-positive (Staphylococcus aureus; Streptococcus pneumonia;
Streptococcus pyogenes) and Gram-negative (Salmonella typhi; Escherichia coli; Pseudomonas
aeroginosa) isolates (obtained via clinical specimens) were utilized.
Findings Nigella sativa aqueous and oil extracts showed a maximum inhibition zone against
E. coli and minimum inhibition against S. pyogenes.
Conclusion Nigella sativa acts against gram-positive as well as gram-negative bacterial
isolates.