م.م. حسام اكريم سلمان
  • Determination of the serum ferritin, liver enzymes, zinc and copper concentration in the serum of thalassemia patients
  • β-Thalassemia is a hereditary blood disorder caused by mutations that affect the synthesis of the β-globin chain of red blood cell hemoglobin. Thalassemia can get an overload of iron in their bodies, either from the disease itself or from frequent blood transfusions. The study aims to evaluate the plasma trace elements and demonstrate the correlation between trace elements and zinc dependent enzyme in Beta Thalassemia patients. Subjects and methods: A cross sectional study was conducted on β-thalassemia major patients whom attended the thalassemia center in Azadi Teaching Hospital. This study was conducted at the first of March 2019 till the end of June 2019, at Kirkuk city - Iraq. Ninety subjects were participated in present study. The subjects were divided into 2 groups. group 1; Sixty thalassemia male patients age 15 to 30 years, transfusion dependent β-thalassemia patients . group 2; Thirty Normal healthy male subjects less than 30 years. Blood sample was taken from patients and control subjects. Serum was used for measurement of ferritin, AST, ALT, ALP, Zinc and copper. Results; The results showed that there was a highly significant elevation in the concentration of serum ferritin in thalassemia male patients as compare to normal control male subjects. There is a highly significant elevation in the serum activities of liver enzymes (AST, ALT and ALP) in thalassemia males when compared to control males. There is there is significant elevation in serum copper in thalassemia patients as compare with healthy controls. However, there was significant reduction in zinc level in thalassemia patients as compare with healthy control.