رحاب صبحي رمضان
  • GENETIC POLYMORPHISM IN BRAF GENE ASSOCIATED WITH THE INCIDENCE OF BRAIN TUMORS IN A SAMPLE OF IRAQI PATIENTS
  • ABSTRACT : A total number of 40 tissue sample from male and female suffering brain tumors were selected and subjected to
    study the Genetic polymorphism in the BRAF gene that cause lethal deterioration in its function. Tissue samples were collected
    from Neuroscience Hospital in 2017 and submitted to molecular analysis using specific primers designed for this purpose.
    Thirty mutations were identified in BRAF region 28 of them are single nucleotide polymorphism (SNPs) with missense
    translation and two deletions inframe type. All these mutation caused a pathogenic effect on the molecular consequence, located
    on chromosome 7, benign at nucleotide 140, 753,333 and ended at nucleotide 140, 781, 600. An important finding that was
    registered through NCBI with accession number LC421658 is a lethal stop codon at position 2032 on BRAF gene appeared
    through gene analysis of Iraqi patients. This mutation was not reported in previous studies. The sequence of BRAF gene
    isolated from Iraqi patient with brain tumor was registered in National Center for Biotechnology Information (NCBI) with
    accession number (NRM33).

     

اخر البحوث المنشورة