ا.م.د. رحاب صبحي رمضان
  • DEFORMATION OF ANDROGEN RECEPTOR GENE CAUSING AN ACCELERATED GROWTH OF GLIOMA IN IRAQI PATIENTS
  • ABSTRACT : A total number of 50 males with malignant brain tumors were selected and subjected to study the involvement of
    androgen receptor in glioma. Tissue samples were collected from Neuroscience Hospital in 2017 and submitted to molecular
    analysis using specific primers designed for this purpose. Testosterone levels measured in all patients with glioma, and
    significant change found in their blood (p <0.001). DNA sequencing for the individually amplified androgen receptor in tumor
    tissue revealed the presence of 53 pathogenic mutations. These included Androgen resistance syndrome, Hypospadias 1, Xlinked,
    Partial
    androgen insensitivity
    syndrome, and
    Prostate
    cancer
    susceptibility.
    Types of mutations
    were frameshift
    1
    mutation, missense 46 variations and non-sense 6 mutations.
    Two Open Reading Frame (ORFs)
    were missing
    from the
    tumor
    cell suggesting the formation of a deformed type of
    AR
    receptor.