ا.م.د. رحاب صبحي رمضان
  • Prognosis of an Inherited Beta Globin Deficiency in Sickle Cell Anemic Iraqi Population
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    Samples of 500 patients suffering from Sickle Cell Disease (SCD) were collected from 
    Ibn Al-Baladi hospital and subjected for blood analysis. Most patients showed an elevated level of
    HbF, HbA2, iron and eosinophels. Two primers were designed to amplify two regions of â-globin
    gene, the first targeting the site from which gene expression begins, and the other is targeting the
    coding region Dgn83. Results showed the presence of a common pathogenic mutation of Arab
    countries at HBB, LOC107133510, LOC110006319 with phenotype MIM 603903, while changes
    were detected at Dgn83 with not attribution to SCD. It is concluded that such mutation is the
    main cause of SCD in Arab countries with specific phenotype that differ from other countries
    around the world.