رحاب صبحي رمضان
  • ANTIBACTERIAL AND ANTI-INflAMMATORY ACTIVITIES OF CALENDULA OFFICINALIS GROWING IN IRAQ
  • This study was designed to evaluated antimicrobial activity of
    Calendula officinalis aqueous extract against some pathogenic
    microorganisms. So that, the aqueous extract of Calendula officinalis
    was screened for its anti-microbial activity using the plate agar
    diffusion method. It was tested against four bacteria species; two
    Gram-positive bacteria (Bacillus subtilis, and Staphylococcus aureus)
    and two Gram-negative bacteria (Escherichia coli  and Pseudomonas
    aeruginosa). The susceptibility of these different bacterial species
    toward the extracts of this plant was compared with each other and
    with selected antibiotic (streptomycin) used as positive control. Result
    showed that aqueous extract of Calendula officinalis had antibacterial 
    This study was designed to evaluated antimicrobial activity of
    Calendula officinalis aqueous extract against some pathogenic
    microorganisms. So that, the aqueous extract of Calendula officinalis
    was screened for its anti-microbial activity using the plate agar
    diffusion method. It was tested against four bacteria species; two
    Gram-positive bacteria (Bacillus subtilis, and Staphylococcus aureus)
    and two Gram-negative bacteria (Escherichia coli  and Pseudomonas
    aeruginosa). The susceptibility of these different bacterial species
    toward the extracts of this plant was compared with each other and
    with selected antibiotic (streptomycin) used as positive control. Result
    showed that aqueous extract of Calendula officinalis had antibacterial This study was designed to evaluated antimicrobial activity of
    Calendula officinalis aqueous extract against some pathogenic
    microorganisms. So that, the aqueous extract of Calendula officinalis
    was screened for its anti-microbial activity using the plate agar
    diffusion method. It was tested against four bacteria species; two
    Gram-positive bacteria (Bacillus subtilis, and Staphylococcus aureus)
    and two Gram-negative bacteria (Escherichia coli  and Pseudomonas
    aeruginosa). The susceptibility of these different bacterial species
    toward the extracts of this plant was compared with each other and
    with selected antibiotic (streptomycin) used as positive control. Result
    showed that aqueous extract of Calendula officinalis had antibacterial activity against gram positive bacteria. The effect of Calendula officinalis was studied on
    male albino mice that included two parts .the first part was the affect of the extract on organ
    physiology like liver and kidney. The second part was the effect of the extract on the bacterial
    infection and wound healing. The study was performed by designing an experiment in which
    four groups of mice were set, every groups is of three mice. The first group was control, the
    second group was administrated with extract oral mouth for 10 days in concentration of
    100mg/kg, the third one was administrated with 75 mg/kg, and the fourth group was feed
    with 25 mg /kg of the extract. After 10 days, mice were killed and put for autopsy histology
    slides were made from kidney and liver and compared with control group. No change was
    observed among studied slides which may indicate that the extract has no toxic effect on
    organs.The other part of the study was the effect of aqueous extract on bacterial infection and
    wound healing. Two groups of mice three in each one were studied. the first one is control
    that was wounded on wounds were infected by staphylococcus aureus  and left for normal
    healing, while the other group was treated by the extract after infecting wounds and contaminating them by staphylococcus aureus. Our results showed an accelerated healing in
    wounds of extract treated group compared with control.
     
     
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