م.د الاء شوقي عبد الباري
  • Comparison of Oral Isotretinoin vs Azithromycin in the Treatment of Acne Vulgaris
  • Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles, common in adolescents, characterized by comedones, papules, pustules, cysts, nodules, and occasionally scars. This study was designed to compare multi B vitamins, folic acid and homocysteine levels in patients with moderate to severe acne vulgaris with those of the apparently healthy control group and to investigate the effect of isotretinoin and azithromycin treatments on these biochemical parameters and comparison between two drugs.
    Methods: This study was conducted on sixty women patients with acne and thirty as a control group. The patients were allocated into two groups, A and B, group A was given 500 mg of azithromycin taken on alternative days for 3 months and group B was given 40mg/day isotretinoin for 3 months.
    Results: The study showed significant differences (p< 0.05) in serum levels of vitamins B6, B7, B12 and folic acid, while no significant difference in serum homocysteine in patient group when compared to control group. The results showed significant positive correlation between serum vitamins and clinical score and significant difference were detected in both group when compared between pre and post treatment.

    Conclusions: The results indicate higher pre-treatment vitamin B12 levels, versus the control group and positive correlation between clinical score and vitamin B12, support the assertion that vitamin B12 plays a role in the etiopathogenesis of acne vulgaris. Both azithromycin and isotretinoin were effective in acne treatment but azithromycin has less side effects

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