م.د الاء شوقي عبد الباري
  • Study the activity of Acid, Alkaline RNase and 5-nucleotidases in sera of Child with Acute lymphoblastic Leukemia
  • ntroduction: Acute lymphoblastic leukemia (ALL) is a cancer of the blood and bone marrow (spongy tissue in the center of bone). Childhood acute leukemia is the most common cancer in children, accounting for approximately one-third of all childhood neoplasms in developed countries. Materials and Methods: Laboratory investigations including serum total protein, acid and alkaline RNas and 5′-nucleotidases enzymes. Blood samples were collected from 60 patients diagnosed to Acute lymphoblastic leukemia (ALL) after one month treatment with induction therapy. Age and sex matched 30 healthy persons selected as control. Results: serum total protein showed A significant decrease in patients group when compared to control group (P< 0.01), Activities and Specific Activities of Serum Alkaline RNase, acid RNase and5′-nucleotidases showed A significant increase in patients group when compared to control group (p< 0.001). Conclusions, The activity of these enzymes in serum give the idea to be suitable in predicting treatment response in the long term follow up of patients. It has been suggested that the measurement of acid RNase, ALK RNase, and 5’-Nucleotidase enzymes could be measured as malignant disease markers

  • PDF